The ultimate guide to your best self, written by your own DNA
Intrinsic Genomics turns your genetics into clear, personalized guides for how your body works, so you can make smarter choices about nutrition, fitness, sleep, and more, without needing a graduate degree to make sense of it. Every guide ends in a short list of specific things to do, not raw data to decode.
One blood draw. Every guide.
A single blood draw produces the DNA file behind all of your Intrinsic Genomics guides. Order your DNA kit once, and each new guide builds on the same data, no extra sample required.
Start with the science of how you nourish your body
Our first three guides each read the same DNA file through a different lens, scored on our proprietary Genetic Friction Score™ so results are easy to read.
My Micronutrients+ Guide™
How well your body manages 30+ vitamins, minerals, and supplements, with food-first guidance for each.
Explore the guide →My Macronutrient Guide™
How you handle protein, carbs, and fats across three dimensions, plus a personalized macro calculator.
Explore the guide →My Nutrition Protocols Guide™
How your genes interact with popular diet, fasting, and exercise protocols, scored on Tolerance and Success.
Explore the guide →Nutrition is our flagship focus — and only the beginning. New guides for exercise & fitness, sleep, and pharmacogenomics (PGx) for over-the-counter medicines are on the way, each built from the same single DNA file.
How it works
The same three steps power every Intrinsic Genomics guide.
We read your DNA file
Built from an Illumina genotyping array covering 1.9M+ common genetic variants, focused on those studied across nutrition, exercise, sleep, and pharmacogenomics.
We apply proprietary polygenic risk scores
Each finding is scored 0–100 using our proprietary polygenic risk scores, combining multiple well-studied variants weighted by published effect sizes.
You get a personalized guide
Clear scorecards and plain-language recommendations you can act on with a health or wellness professional.
Meet your Genetic Friction Score™
Every guide uses the same scale. Think of it less like a grade and more like a resistance meter. A low score means your genes work with you; a higher score means they create obstacles worth paying attention to.
Built to be trustworthy
We curate the strongest research, connect it to your DNA, and translate it into a guide you can actually use. Our design choices are simple, transparent, and deliberately conservative.
Evidence first
Every finding clears three filters: peer-reviewed research, a replicated effect, and clinically meaningful relevance. We separate “interesting” from “actionable.”
Polygenic, not single-gene
Each score combines several well-studied variants rather than one marker, so a single quirky finding can’t move the needle.
Answers, not data
We don’t hand you a spreadsheet of variants. Each guide surfaces a few top priorities with specific, do-this-next steps in plain language.
Start with the guide that fits your goals
Order your DNA kit once and unlock personalized, evidence-first guidance you can use with your provider.
Explore the GuidesIG requires one blood draw that can be used for all of your guides. If you’ve already had your blood drawn, you’re all set. If not, you’ll need to order your DNA kit to produce your guides.